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Viswanathan et al

Researchers have looked into this stress-modulating activity across various models, and the idea that DSIP might help restore homeostasis after stressinstead of just suppressing the responseis pretty interesting

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A previous study reported that vitamin C could prevent monosodium iodoacetate (MIA) induced changes such as cell growth inhibiting and oxidative stress increasing, apoptosis, MMPs increasing, and proteoglycan loss in a chondrosarcoma cell line (SW1353) [160]

Overall, the ES paradigms affected behavior in 82.00% of the cases, this was consistent across the behavioral domains assessed (depressive-like behavior 82.35%, anxiety-like behavior 78.57%, cognitive deficits 85.00% and social deficits 80.00% and other ES-induced behaviors 90.00%)